منابع مشابه
Endocannabinoids mediate bidirectional striatal spike-timing-dependent plasticity.
KEY POINTS Although learning can arise from few or even a single trial, synaptic plasticity is commonly assessed under prolonged activation. Here, we explored the existence of rapid responsiveness of synaptic plasticity at corticostriatal synapses in a major synaptic learning rule, spike-timing-dependent plasticity (STDP). We found that spike-timing-dependent depression (tLTD) progressively dis...
متن کاملEndocannabinoids Mediate Synaptic Plasticity At
30 Activation of Type 1 cannabinoid receptors (CB1R) in many central nervous system 31 structures induces both short and long term changes in synaptic transmission. Within 32 mammalian striatum, endocannabinoids (eCB) are one of several mechanisms that 33 induce synaptic plasticity at glutamatergic terminals onto medium spiny neurons. 34 Striatal synaptic plasticity may contribute a critical co...
متن کاملEndocannabinoids Mediate Synaptic Plasticity at Mixed Synapses
Endocannabinoids are generally known to suppress excitatory or inhibitory synaptic transmission. Now, in an elegant series of experiments, Cachope et al. reveal a novel signaling pathway whereby endocannabinoids indirectly potentiate mixed chemical and electrical synapses. Gap junction-mediated transmission can thus be potentiated via distinct frequency-dependent mechanisms.
متن کاملEndocannabinoids and striatal function: implications for addiction-related behaviours
Since the identification and cloning of the major cannabinoid receptor expressed in the brain almost 25 years ago research has highlighted the potential of drugs that target the endocannabinoid system for treating addiction. The endocannabinoids, anandamide and 2-arachidonoyl glycerol, are lipid-derived metabolites found in abundance in the basal ganglia and other brain areas innervated by the ...
متن کاملStriatal Spine Plasticity in Parkinson's Disease
Striatal dopamine (DA) denervation results in a significant loss of dendritic spines on medium spiny projection neurons in Parkinson's disease. In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated parkinsonian monkeys, spines contacted either by cortical or thalamic glutamatergic terminals are severely affected on both direct and indirect striatofugal neurons. In rodents, indirect pathway ne...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Parkinsonism & Related Disorders
سال: 2012
ISSN: 1353-8020
DOI: 10.1016/s1353-8020(11)70041-4